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THE CREATINE
RESEARCH GUIDE
Here we will post many of the research topics, questions of areas of concern regarding creatine, and also various
individual and group findings with respect to the usage of creatine. We have spent many months re-producing these
articles and hope they can clear up any unanswered questions you still may have about creatine and its benefits and side effects.
Why have I been hearing so much about creatine and neuromuscular disorders?
Two scientific studies have indicated that creatne may be beneficial for neuromuscular disorders. First, a study by MDA-funded researcher M. Flint Beal of Cornell University Medical Center demonstrated that creatine was twice as effective as the prescription drug riluzole in extending the lives of mice with the degenerative neural disease amyotrophic lateral sclerosis (ALS, or Lou Gehrig's disease). Second, a study by Canadian researchers Mark Tarnopolsky and Joan Martin of McMaster University Medical Center in Ontario found that creatine can cause modest increases in strength in people with a variety of neuromuscular disorders. Beal's work was published in the March 1999 issue of Nature Neuroscience and the second paper was published in the March 1999 issue of Neurology.
The amount of phosphocreatine in the muscles of people with some neuromuscular disorders, such as mitochondrial myopathies or inflammatory myopathies, is lower than normal. Researchers suspect that creatine supplementation in these people may improve muscle strength by bolstering the muscles' energy stores.
The study reported in the March issue of Neurology examined the effects of creatine on 81 people with neuromuscular disorders, including muscular dystrophies (myotonic, Becker, limb-girdle), a metabolic myopathy (McArdle's), mitochondrial myopathies (MELAS, MNGIE and others), spinal muscle atrophy, inflammatory myopathies (polymyositis, dermatomyositis, inclusion body myositis) and congenital myopathies (multicore and central core disease).
It's important to note that the authors found an average increase in strength over the entire group of people with neuromuscular disorders in response to creatine. There didn't appear to be particular neuromuscular disorders that responded better or worse to creatine supplementation, but the sample sizes were too small to rule out greater or lesser gains for particular disorders. This was a brief (less than two weeks) study and longer studies in groups of people with the same neuromuscular disorders are necessary to address this question.
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Creatine And ALS
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